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Journal of the Acoustical Society of America / Volume 131 / Issue 1 / BIOACOUSTICS [80]

Modeling of thermal effects in antivascular ultrasound therapy

J. Acoust. Soc. Am. Volume 131, Issue 1, pp. 540-549 (2012); (10 pages)

Benjamin J. Levenback1, Chandra M. Sehgal1, and Andrew K. W. Wood2

1Department of Radiology, School of Medicine, University of Pennsylvania, 1 Silverstein, 3400 Spruce Street, Philadelphia, Pennsylvania 19104
2Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104

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Antivascular ultrasound consisting of low-intensity sonication in the presence of circulating microbubbles of an ultrasound contrast agent has been demonstrated to disrupt blood flow in solid cancers. In this study a mathematical framework is described for the microbubble-induced heating that occurs during antivascular ultrasound. Biological tissues are modeled as a continuum of microbubble-filled vasculature, cells, and interstitial fluids with compressibility equal to the sum of the compressibility of each component. The mathematical simulations show that the absorption of ultrasound waves by viscous damping of the microbubble oscillations induced significant local heating of the tissue vasculature. The extent and the rate of temperature increase not only depends on the properties of the microbubbles and the sonication parameters but is also influenced markedly by the blood flow. Slow flow conditions lead to higher tissue temperatures due to a stronger interaction between microbubbles and ultrasound and reduced heat dissipation. Because tumors have slower blood flow than healthy tissue, the microbubble-induced ultrasound antivascular therapy is likely to affect cancerous tissue more extensively than healthy tissue, providing a way to selectively target the vasculature of cancers.

© 2012 Acoustical Society of America

ACKNOWLEDGMENT

This work was supported by NIH Grant No. CA139657.

Article Outline

  1. INTRODUCTION
  2. MODEL AND METHODS
    1. Absorption of ultrasound by an ensemble of microbubbles in tissue vasculature
      1. Ensemble of identical microbubbles
      2. Ensemble of bubbles with a size distribution
    2. Bubble-enhanced heating in the presence of blood flow
    3. Effect of blood flow on ultrasound–microbubble interaction
  3. RESULTS
    1. Microbubble ensembles with distributed radii
    2. Ultrasound absorption by microbubble ensembles
    3. Temperature elevation
  4. DISCUSSION AND CONCLUSION

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KEYWORDS and PACS

Keywords

biomedical ultrasonics, bubbles, cancer, cellular biophysics, cooling, damping, haemodynamics, heat treatment, tumours, ultrasonic absorption, ultrasonic therapy

PACS

  • 43.80.Cs

    Acoustical characteristics of biological media: molecular species, cellular level tissues

  • 43.80.Sh

    Medical use of ultrasonics for tissue modification (permanent and temporary)

  • 43.80.Gx

    Mechanisms of action of acoustic energy on biological systems: physical processes, sites of action

ARTICLE DATA

History
Received 06 Apr 2011
Accepted 13 Oct 2011
Revised 12 Oct 2011
Digital Object Identifier
http://dx.doi.org/10.1121/1.3662048

PUBLICATION DATA

ISSN

0001-4966 (print)  

Publisher

$abstract.society.value is a Member of CrossRef Acoustical Society of America

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