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Journal of the Acoustical Society of America / Volume 121 / Issue 1 / BIOACOUSTICS [80]

Microbubble spectroscopy of ultrasound contrast agents

J. Acoust. Soc. Am. Volume 121, Issue 1, pp. 648-656 (2007); (9 pages)

Sander M. van der Meer1, Benjamin Dollet1, Marco M. Voormolen2, Chien T. Chin2, Ayache Bouakaz2, Nico de Jong2, Michel Versluis1, and Detlef Lohse1

1Physics of Fluids Group, Department of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
2Department of Experimental Echocardiography, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands

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A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.

© 2007 Acoustical Society of America

ACKNOWLEDGMENTS

We would like to thank Marlies Overvelde and Jeroen Sijl for fruitful discussions.
This work is part of the research program of the Stichting FOM, which is financially supported by NWO. We acknowledge the Interuniversity Cardiology Institute of the Netherlands (ICIN) and the Senter Novem agency of the Dutch Ministry of Economic Affairs for their financial support. We acknowledge Bracco Research, Geneva, for supplying contrast agents (BR-14 and SonoVue™).

Article Outline

  1. INTRODUCTION
  2. BUBBLE SPECTROSCOPY
    1. The microbubble as a linear oscillator
    2. Simulation example: Power spectrum and resonance curve
    3. Analysis of the resonance curve
  3. EXPERIMENTS
    1. The setup
    2. Radius-time curves determination
    3. Data processing
  4. RESULTS
    1. Eigenfrequency
    2. Damping
  5. DISCUSSION AND CONCLUSIONS
    1. Accuracy of the measurements
    2. Nonlinear pressure and wall effects
    3. Conclusions

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KEYWORDS and PACS

Keywords

bubbles, biomedical ultrasonics, cavitation, nonlinear acoustics

PACS

  • 43.80.Qf

    Medical diagnosis with acoustics

  • 43.80.Vj

    Acoustical medical instrumentation and measurement techniques

  • 43.35.Ei

    Acoustic cavitation in liquids

ARTICLE DATA

History
Received 13 Jul 2006
Accepted 16 Oct 2006
Revised 16 Oct 2006
Digital Object Identifier
http://dx.doi.org/10.1121/1.2390673

PUBLICATION DATA

ISSN

0001-4966 (print)  

Publisher

$abstract.society.value is a Member of CrossRef Acoustical Society of America

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